File:Di tert butyl 4 nitrophenol.pdf: Difference between revisions

Description

This source is from a technical report detailing a study on the toxicokinetic evaluation of 2,6-DI-tert-butyl-4-Nitrophenol (DBNP) in male rats following oral gavage. The research, supported by the Office of Naval Research (ONR), aimed to gain information on the distribution and excretion of DBNP post an oral gavage. The report mentions that DBNP is a contaminant found on the interior surfaces of submarines. It is produced when oil mist from synthetic steam turbine lubricants containing the antioxidant 2,6-Di-tert-butylphenol is nitrated during passage through the submarine air filtration system. US sailors may be exposed to DBNP for prolonged periods. Potential human risk due to dermal and respiratory exposure is suspected to be low due to minimal solubility, but oral ingestion in food and water is a possible risk. The study found that orally dosed DBNP in a canola oil/DSMO vehicle was readily absorbed from the gastrointestinal tract, differentially distributed to various organ compartments, and primarily cleared through the feces.

Abstract

This technical report details a study on 2,6-DI-tert-butyl-4-Nitrophenol (DBNP), identified as a contaminant found on the interior surfaces of submarines. DBNP originates from the nitration of an antioxidant in synthetic steam turbine lubricants. The study evaluated the distribution and excretion of DBNP in rats following oral exposure.