"To Put This In Perspective

SAN ANTONIO, May 17, 2024 - A strict "keto-friendly" diet popular for weight loss and diabetes, Supraketo Official depending on both the diet and individual, might not be all that friendly. A new study led by researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) found that a continuous long-term ketogenic diet may induce senescence, or aged, cells in normal tissues, with effects on heart and kidney function in particular. However, an intermittent ketogenic diet, with a planned keto vacation or break, did not exhibit any pro-inflammatory effects due to aged cells, according to the research. The findings have significant clinical implications suggesting that the beneficial effect of a ketogenic diet might be enhanced by planned breaks. "To put this in perspective, 13 million Americans use a ketogenic diet, and we are saying that you need to take breaks from this diet or there could be long-term consequences," said David Gius, MD, PhD, assistant dean of research and professor with the Department of Radiation Oncology in the Joe R. and Teresa Lozano Long School of Medicine at UT Health San Antonio, and associate cancer director for translational research at the institution’s Mays Cancer Center.



He is lead author of the new study titled, "Ketogenic diet induces p53-dependent cellular senescence in multiple organs," published May 17 in the journal Science Advances. Other authors also are with the Department of Radiation Oncology and Mays Cancer Center, as well as the Sam and Ann Barshop Institute for Longevity and Aging Studies, Center Supraketo for Ketosis Precision Medicine, School of Nursing, and Division of Nephrology in the Department of Medicine at UT Health San Antonio; and both the Houston Methodist Cancer Center and Houston Methodist Research Institute. A ketogenic diet, popularly known as keto-friendly, is a high-fat, low-carbohydrate diet that leads to the generation of ketones, a type of chemical that the liver produces when it breaks down fats. While a ketogenic diet improves certain health conditions and is popular for weight loss, pro-inflammatory effects also have been reported. The new study shows that mice on two different ketogenic diets, and at different ages, induce cellular senescence in multiple organs, including the heart and kidney.



However, this cellular senescence was eliminated by a senolytic, or a class of small molecules that can destroy senescence cells, and prevented by administration of an intermittent ketogenic diet regimen. "As cellular senescence has been implicated in the pathology of organ disease, our results have important clinical implications for understanding the use of a ketogenic diet," Gius said. UT Health San Antonio is the largest academic research institution in South Texas with an annual research portfolio of $413 million. The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is one of the country’s leading health science universities and is designated as a Hispanic-Serving Institution by the U.S. Department of Education. With missions of teaching, research, patient care and community engagement, its schools of medicine, nursing, dentistry, health professions, graduate biomedical sciences and public health have graduated more than 42,550 alumni who are leading change, advancing their fields and renewing hope for patients and their families throughout South Texas and the world. Stay connected with The University of Texas Health Science Center at San Antonio on Facebook, Twitter, LinkedIn, Instagram and YouTube. The UT Health San Antonio Joe R. and Teresa Lozano Long School of Medicine is listed among U.S. News & World Report’s best medical schools, ranking in the top 30% nationwide for research. The Mays Cancer Center at UT Health San Antonio is one of only four National Cancer Institute-designated Cancer Centers in Texas. The Mays Cancer Center provides leading-edge cancer care, propels innovative cancer research and educates the next generation of leaders to end cancer in South Texas.



Each week I’m trying to help take the stress out of a keto diet by giving you FIVE low-carb dinners plus a bonus meal prep recipe that helps keep you on track! This week your bonus is a tray of delicious Double Chocolate Sheet Pan Cookies-Only 3.6 net carbs a piece! When you click through to each individual recipe, it’ll take you to the full, detailed, step-by-step instructions. This includes a printable recipe card that includes nutrition information. To figure out the net carb count, subtract the amount of fiber from the amount of total carbs. At the bottom of this post, you’ll find a printable meal plan (with space to fill in your own needs & weekend plans) as well as an organized grocery list to help make things even easier. If you’re having trouble printing this, make sure you have your ad blocker disabled. If you like to meal prep to get ahead for the week, I’ve even included tips for preparing each meal in advance.



So sit back and Supraketo for Ketosis relax-I’ve got dinner covered! These Double Chocolate Sheet Pan Cookies are perfect for multiple reasons. 1.) They’re only 3.6 net carbs, 2.) They’re unbelievably rich and fudgy, and 3.) They don’t require chilling like most keto desserts do! You could prepare, bake, and allow these to cool in just about 30 minutes! If you don’t think you’ll eat 24 in a week (or if you want to make a double batch for next week), these are easily freezable! Just double wrap each cookie in plastic wrap and store in a freezer-safe container for a few months! This Chicken Philly Cheesesteak Skillet is perfect for a Monday-a one-pan meal packed with tons of veggies! Don’t worry, though, picky eaters; the melty cheesy goodness makes it feel like a comfort food! It’s ready within 30 minutes with very little to clean up, AND a big serving (about 1 1/4 cup) only adds 4.5 net carbs!